Identification of G-Protein Coupled Receptor Kinase 2 in Paired Helical Filaments and Neurofibrillary Tangles
نویسندگان
چکیده
منابع مشابه
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.
G-protein coupled receptor kinases (GRKs) constitute a serine/threonine kinase family playing a major role in agonist-induced phosphorylation and desensitization of G-protein coupled receptors. Recently, GRK2 and GRK5 have been demonstrated to phosphorylate alpha-synuclein (Ser129) and other synuclein isoforms. We studied colocalization of GRK2, GRK5, alpha-synuclein, and tau in neurodegenerati...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 2006
ISSN: 0022-3069
DOI: 10.1097/01.jnen.0000248542.82681.12